I'm Ana Y. Morales-Arce,
a research fellow at IZSVe in Verona, Italy.

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About

I am a molecular biologist and population geneticist with broad interests in evolutionary biology, pathogen genomics, and molecular anthropology. I earned my B.Sc. in Biotechnology and M.Sc. in Anthropological Genetics from the Tecnológico de Costa Rica and the University of Costa Rica, respectively, and my Ph.D. in Archaeogenetics from the University of Calgary, where I studied pre-Columbian ancestry and population movements in Central America and Mexico using mitochondrial ancient DNA. My doctoral research was supported by a Wadsworth Fellowship from the Wenner-Gren Foundation. I subsequently held a Postdoctoral Fellowship at the Center for Evolution & Medicine at Arizona State University, where I worked on evolutionary models of within-host pathogen dynamics under the guidance of Dr. Jeffrey Jensen and Dr. Anne Stone. Later, at the Instituto Gulbenkian de Ciência in Portugal and the University of Bern in Switzerland, I investigated the dynamics of evolutionary rescue in influenza A virus. Since 2023, I have been based in Verona, Italy, as a research fellow at the Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe). My current work focuses on molecular diagnostics and research on avian and animal pathogens, particularly Mycoplasma species. My research includes pathogen genomics, genomic surveillance, molecular typing, and the development of molecular tools for pathogen detection. I also contribute to research on antimicrobial resistance and apply my background in ancient DNA to the development of approaches for recovering Mycoplasma DNA from environmental samples.

Research

My current research focuses on the molecular diagnosis and characterization of avian Mycoplasma, particularly Mycoplasma synoviae and Mycoplasma gallisepticum. At the Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), I work at the interface between diagnostic microbiology and research, using molecular and genomic approaches to improve pathogen detection, characterization, and epidemiological surveillance. A major component of my research involves the development, evaluation, and application of molecular diagnostic methods, including real-time PCR and sequencing-based approaches. I am particularly interested in integrating molecular diagnostics with genomic and epidemiological data to investigate strain diversity, transmission patterns, and the population dynamics of avian Mycoplasma in poultry populations. My work also incorporates molecular typing and comparative genomics to investigate the genetic diversity and evolution of Mycoplasma populations. Building on my background in population genetics and ancient DNA, I am interested in applying genomic and molecular approaches to challenging diagnostic samples and in developing strategies to recover and characterize pathogen DNA from environmental and other complex biological samples.

Publications

2026 Stefani, Elisabetta and Morales-Arce, Ana Y and Nai, Giorgia and Righetti, Verdiana and Colò, Beatrice and Prataviera, Davide and Giacomelli, Martina and Catania, Salvatore. Molecular typing of Mycoplasma synoviae in industrial and backyard poultry: a 14-year study in Italy
2022 Morales-Arce AY, Smith-Guzmán NE . Human genetic diversity through time in Central America: Current advances and future directions. In: Roberto Herrera, Yahaira Núñez-Cortés, and Geoffrey McCafferty, editors. The Cultural Mosaic of Central America: Diverse Archaeologies of the Archaeology of Diversity. Salt Lake City, UT: University of Utah Press. In review.
2022 Claudia Bank, Mark A. Schmitz, Morales-Arce AY. Evolutionary models predict potential mechanisms of escape from mutational meltdown. Front. Virol. 2:886655.
2022 Susanna Sabin, Morales-Arce AY, Susanne P. Pfeifer, and Jeffrey D. Jensen. Comparative population genomics of Mycobacterium canettii and Mycobacterium tuberculosis. G3 Genes|Genomes|Genetics, 12(5):jkac055.
2022 Morales-Arce AY, Johri P, Jensen JD. Inferring the distribution of fitness effects in patient-sampled and experimental virus populations: two case studies. Heredity, 128, 79–87
2021 Songül Alpaslan-Roodenberg, David Anthony, Hiba Babiker, Eszter Bánffy, Thomas Booth, Patricia Capone, Arati Deshpande-Mukherjee, Stefanie Eisenmann, Lars Fehren-Schmitz, Michael Frachetti, Ricardo Fujita, Catherine J. Frieman, Qiaomei Fu, Henry Louis Gates Jr., Victoria Gibbon, Wolfgang Haak, Mateja Hajdinjak, Kerstin P. Hofmann, Brian Holguin, Takeshi Inomata, Hideaki Kanzawa-Kiriyama, William Keegan, Janet Kelso, Johannes Krause, Ganesan Kumaresan, Chapurukha Kusimba, Sibel Kusimba, Carles Lalueza-Fox, Bastien Llamas, Scott MacEachern, Swapan Mallick, Hirofumi Matsumura, Janet Monge, Morales-Arce AY, Giedre Motuzaite Matuzeviciute, Veena Mushrif-Tripathy, Nathan Nakatsuka, Rodrigo Nores, Christine Ogola, Mercedes Okumura, Nick Patterson, Ron Pinhasi, S.P.R. Prasad, Mary E. Prendergast, Jose Luis Punzo, David Reich, Rikai Sawafuji, Elizabeth Sawchuk, Stephan Schiffels, Jakob Sedig, Svetlana Shnaider, Kendra Sirak, Pontus Skoglund, Viviane Slon, Meradeth Snow, Marie Soressi, Matthew Spriggs, Philipp W. Stockhammer, Anna Szécsényi-Nagy, K. Thangaraj, Vera Tiesler, Ray Tobler, Chuan-Chao Wang, Christina Warinner, Surangi Yasawardene, Muhammad Zahir. Ethics of DNA Research on Human Remains: Five Globally Applicable Guidelines. Nature 599, 41–46.
2020 Morales-Arce AY, Sabin SJ, Stone AC, Jensen JD. The population genomics of within-host Mycobacterium tuberculosis. Heredity, 126, 1–9.
2020 Morales-Arce AY, Harris RB, Stone AC, Jensen JD. Evaluating the contributions of purifying selection and progeny-skew in dictating within-host Mycobacterium tuberculosis evolution. Evolution, 74-5:992-1001.
2019 Morales-Arce AY, McCafferty G, Hand J, Schmill N, McGrath K, Speller C. Ancient mitochondrial DNA and population dynamics in Postclassic Central Mexico: Cholula (A.D. 900-1350) and Tlatelolco (A.D. 1325-1521). Archaeological and Anthropological Sciences, 11: 3459-3475.
2017 Morales-Arce AY, Hofman CA, Duggan AT, Benfer AK, Katzenberg MA, McCafferty G, Warinner C. Successful reconstruction of whole mitochondrial genomes from ancient Central America and Mexico. Scientific Reports. 7(1):18100.
2017 Morales-Arce AY, Snow MH, Kelley JH, Katzenberg MA. Ancient mitochondrial DNA and ancestry of Paquimé inhabitants, Casas Grandes (1200-1450 A.D.). American Journal of Physical Anthropology, 163: 616-626.
2015 Morales-Arce AY. Ancient DNA studies in Mesoamerica: major contributions and limitations. Proceedings of the Annual Chacmool Archaeological Conference 47: 139-148.
2014 McCafferty G, Carrol G, Manion J, Morales-Arce AY, Smekal M. Huesos Nicaragua: Creación de un Laboratorio de Bio-Arqueología en la Universidad Nacional/ Bones Nicaragua: Creation of a Bio-Archaeology Laboratory in the National University. Mi Museo y Vos 29: 13-16.
2012 Morales-Arce AY, Alvarado Rojas S, Calvo Brenes M, Contreras Rojas J, Raventós Vorst. Un acercamiento al contenido cultural de los delirios de personas con esquizofrenia de Costa Rica/ Cultural content of delusions in people with schizophrenia from Costa Rica. Cuadernos de Antropología, 22.
2012 Morales-Arce AY. Lactose Intolerance in Indigenous Groups of Lower Central America. Genetic variation and its potential health problem. LAP LAMBERT Academic Publishing, Saarbrücken, Germany. 84p.

Courses/ teaching experience

Year University Role Topic Enrollment
2022 University of Bern Teaching Assistant Statistics for biologists 70
2020 Arizona State University Original lectures contribution Advanced evolutionary medicine (online class) 30
2017 University of Calgary Instructor of Record Introduction to Primatology and Human Evolution 200
2014-2016 University of Calgary Teaching Assistant Graduate Head Teaching Assistant. Laboratory: Introduction to Physical Anthropology 8 labs of 22 students each
2015 University of Calgary Teaching Assistant Laboratory: Introduction to Archaeology 2 labs of 20 students each
2015 University of Calgary Teaching Assistant Archaeology & Popular Culture - Frauds, Myths & Mysteries 100
2013 University of Calgary Teaching Assistant Ethnographic Survey of Latin America 200
2012 University of Costa Rica Instructor of Record Molecular Basis of Human Phylogeny 20
2011 University of Costa Rica Instructor of Record Principles of Population Genetics 30
2011 University of Costa Rica Instructor of Record Biological Anthropology 30-40

Videos

Conferences

2022 Bridging experiments and simulations to study the effect of mutagenic drugs on influenza A virus populations. European Society for Evolutionary Biology. Prague, CZE.
2022 SIBdays. Evolution and phylogeny. Biel, CH; Session organizer
2022 Biology22. University of Basel. Basel, CH; talk
2020 American Association of Physical Anthropologists. Los Angeles, CA, USA; talk
2019 Society for Molecular Biology and Evolution (SMBE). Manchester, UK; poster
2019 The Evolutionary Genetics of Infectious Disease, Carleton University, ON; talk
2019 Society for American Archaeology 84th Annual Meeting (SAA), Albuquerque, NM; talk
2017 Chacmool Conference, Calgary, AB; Session organizer and talk
2016 49th Annual Meeting of the Canadian Archaeological Association (CAA), Whitehorse, Yukon; talk
2016 Latin American Research Center, Graduate Student Symposium (LARC), Calgary, AB; talk
2016 Society for American Archaeology, Orlando, FL; talk
2016 6th Annual Interdisciplinary Archaeology Research Conference (UCLA), Los Angeles, CA; talk
2015 48th Chacmool Conference, Calgary, AB; talk
2015 Society for American Archaeology, San Francisco, USA; talk
2015 Methods in Ecology and Evolution: Next Generation Ecology and Evolution, Calgary, AB; talk
2014 47th Chacmool Conference. Calgary, AB; talk
2014 Society for American Archaeology, Austin, TX; talk
2011 Congreso Centroamericano de Antropologia, Tegucigalpa, Honduras; talk
2010 Nutrition and Health Congress. San José, Costa Rica; talk
2009 Darwin200 Celebration International Simposium, Alajuela, Costa Rica; talk

Contact

Verona,Italy
[email protected]
+39 339 590 6953